|
KMID : 0379520040200040381
|
|
한국독성학회지
2004 Volume.20 No. 4 p.381 ~ p.389
|
|
|
Comparison of Single-Dose Toxicity by Intravenous Infusion or Bolus Injection with CKD-602, a Camptothecin Anticancer Agent in Rats (II): Hematological and Serum Biochemical, and Histopathological Changes
|
|
Kim Choong-Yong
Yang Byung-Chul
Kim Joon-Kyum
Kim Jong-Choon
Kim Yong-Bum
Kang Boo-Hyon
Han Sang-Seop
|
|
|
Abstract
|
|
|
|
The toxicity of CKD-602 was investigated at doses of 3, 9, and 27 mg/kg in rats, when the same total dose of CKD-602 was administered over 24 hr-continuous infusion or bolus injection. At 3 and 9 mg/kg, the 24-hr infusion group showed a more decreased WBC count on day 3, compared with the bolus group. Administration of CKD-602 caused more toxic effects such as the significant decreases of RBC counts, hematocrit, hemoglobin, and platelet count on day 7 post-administarion in the 24-hr infusion group than in the bolus group. Administration of CKD-602 also caused histopathological changes such as extramedullary hemopoiesis of liver and spleen, hyperplasia of femoral bone marrow, and caecal dilation. These toxic effects were more severe in the 24-hr infusion group than in the bolus injection group, indicating that the toxicity of CKD-602 may be dependant upon the duration of administration.
|
|
|
KEYWORD
|
|
|
CKD-602, Infusion, Toxicity, Rat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|